Our teams: OPPaLE

After obtaining my state midwifery diploma, I became involved in public health research and in 2020 I obtained a PhD in epidemiology on the links between preconception maternal nutrition, foetal development and placental epigenetics. My work has identified key associations between pre-conception weight variations, dietary intake, foetal growth and placental epigenetic mechanisms. As a postdoctoral researcher at University College Dublin, I broadened my research to examine the links between the diet and lifestyle of mothers and fathers and the epigenetics of their children.

I then joined the European EndObesity consortium and coordinated a work programme focusing on family health behaviours during the first 1,000 days of life and their influence on childhood obesity. I defined the research objectives and managed collaborations between several European institutions. At McGill University in Canada, I broadened my expertise in perinatal mental health and children's socio-emotional development. I developed strong skills in mixed methods and qualitative research. Finally, in September 2025, I rejoined the OPPaLE team to work on bariatric surgery and child development.

Research interests

  • Nutritional epidemiology
  • Childhood obesity prevention
  • Epigenetic mechanisms

Key publications

  • Lecorguillé M, Jacota M, de Lauzon-Guillain B, Forhan A, Cheminat M, Charles MA, Heude B. An association between maternal weight change in the year before pregnancy and infant birth weight: ELFE, a French national birth cohort study. PLoS Med. 2019 Aug 20;16(8):e1002871. doi: 10.1371/journal.pmed.1002871.


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  • Lecorguillé M, Schipper MC, O’Donnell A, Aubert AM, Tafflet M, Gassama M, Douglass A, Hébert JR, de Lauzon-Guillain B, Kelleher C, Charles M-A, Phillips CM, Gaillard R, Lioret S and Heude B (2023) Impact of parental lifestyle patterns in the preconception and pregnancy periods on childhood obesity. Front. Nutr. 10:1166981. doi: 10.3389/fnut.2023.1166981


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  • Lecorguillé M, McAuliffe FM, Twomey PJ, Viljoen K, Mehegan J, Kelleher CC, Suderman M, Phillips CM. Maternal Glycaemic and Insulinemic Status and Newborn DNA Methylation: Findings in Women With Overweight and Obesity. J Clin Endocrinol Metab. 2022 Dec 17;108(1):85-98. doi: 10.1210/clinem/dgac553.
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Links

Theses

Maternal nutrition before pregnancy, fetal growth and placental epigenetics

Marion Lecorguillé

Promotion : 2017 - 2020

Supervisor.s : Marie-Aline Charles, Barbara Heude

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