Our teams: OPPaLE

With a background in biostatistics, I joined Inserm in 2001. Holder of a PhD and a French Habilitation to Supervise Doctoral Research (HDR), I conduct research on environmental risk factors for childhood cancers within the OPPaLE team (Obstetric, Perinatal, Paediatric Life course Epidemiology) at the Centre for Research in Epidemiology and Statistics (CRESS, UMR 1153). I also contribute to the team’s leadership as Deputy Co-Director.

I am responsible for the GEOCAP program (Géolocalisation des cancers pédiatriques) dedicated to research on environmental risk factors of childhood cancer, based on the French National registry of childhood cancer. Using geocoded data and geographical information system, we have conducted research projects on several environmental factors: pesticides in the vicinity of crops, traffic-related air pollution, natural background radiation (RadoNorm Europena project), extremely low frequency magnetic field close to overhead high voltage powerlines, infections (e.g. COVID-19) etc. We also account for the socio-economic individual and contextual environment.

Since completing my PhD, I have also developed expertise in the field of childhood cancer surveillance in France (spatial and temporal variations in incidence, cluster investigations, surveillance of at-risk populations).

French national registry of childhood cancer (RNCE) - https://rnce.inserm.fr/en/

RadoNorm - Towards effective radiation protection based on improved scientific evidence and social considerations – focus on Radon and NORM https://www.radonorm.eu/

Research interests

  • Environmental risk factors of childhood cancer
  • Socio-economic determinants of exposures
  • Geographic information system
  • Incidence and survival of childhood cancer
  • Spatial and temporal variations in childhood cancer incidence rates
  • Cluster investigation

Key publications

  • Mancini M, Hémon D, de Crouy-Chanel P, Guldner L, Faure L, Clavel J, Goujon S. Association between residential proximity to viticultural areas and childhood acute leukemia risk in mainland France – GEOCAP case-control study, 2002-2013 Environ Health Perspect 2023. In press. doi: 10.1289/EHP12634
  • Berlivet J, Hémon D, Cléro É, Ielsch G, Laurier D, Guissou S, Lacour B, Clavel J, Goujon S. Ecological association between residential natural background radiation exposure and the incidence rate of childhood central nervous system tumors in France, 2000-2012. J Environ Radioact. 2020 Jan;211:106071. doi: 10.1016/j.jenvrad.2019.106071. Epub 2019 Oct 7. PMID: 31600676.
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  • Goujon S, Kyrimi E, Faure L, Guissou S, Hémon D, Lacour B, Clavel J. Spatial and temporal variations of childhood cancers: Literature review and contribution of the French national registry. Cancer Med. 2018 Oct;7(10):5299-5314. doi: 10.1002/cam4.1774. Epub 2018 Sep 19. PMID: 30230715; PMCID: PMC6198217.
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