PhD student: Rosalie Delvert
Title: Association between maternal diet during pregnancy and development of allergic and respiratory diseases in children
Supervisors: Raphaëlle Varraso, Blandine de Lauzon-Guillain, Annabelle Bédard
Doctoral school: EDSP (ED 570), Public Health, Université Paris-Saclay
Funding: ED Programme blanc GS-SanPub
Allergies and respiratory diseases are highly prevalent in children. These diseases are multifactorial, involving both genetic and environmental factors. According to the DOHaD (Developmental Origins of Health and Disease) hypothesis, early life exposures can have long-term effects on individual health. As a modifiable factor, maternal diet during pregnancy may be a potential lever for preventing allergic and respiratory diseases.
This is why, the main objective of this PhD is to study the associations between maternal diet during pregnancy and allergic and respiratory diseases in children in EDEN (https://eden.vjf.inserm.fr/) and ELFE (https://www.elfe-france.fr/), two French birth cohorts.
More specifically, it consists of three objectives:
- One concerns maternal diet quality during pregnancy, focusing on adherence with nutritional guidelines during pregnancy,
- The second deals with specific mechanistic hypotheses, such as the effect of an anti-inflammatory or antioxidant-rich diet,
- And the last focuses on specific issues linked to changing dietary habits (plant-based diet, consumption of industrial products, Western diet).
For these three objectives, the potential mediating or modulating effect of breastfeeding and complementary feeding on the relationship between maternal diet and allergic and respiratory diseases will be examined.