Our teams: EpiAgeing
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I trained in human nutrition and obesity prevention, followed by a PhD in Epidemiology. The PhD introduced me to research on ageing as the focus was on the impact of nutrition on physical function in older adults. My training was in Spain, although I did a 3-month research stay in Amsterdam and I used data from the UK biobank (UK) and LASA (Netherlands) cohorts in my PhD. For the post-doctoral period I moved to the EpiAgeing group (INSERM, Paris) where I’m currently doing my research.
My primary research is on the role of obesity and metabolic factors in shaping old-age outcomes such as dementia, disability, and frailty. My research on ageing uses a population health perspective in order to identify putative prevention targets and I am increasingly using the lifecourse approach which takes the view that exposures over the lifespan affect ageing outcomes.
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Research interests
- Alzheimer’s disease and related dementias
- Obesity
- Frailty
- Disability
- Nutrition
- Plasma Biomarkers
- Coffee
- Physical limitations
Key publications
- Machado-Fragua MD, Fayosse A, Yerramalla MS, van Sloten TT, Tabak AG, Kivimaki M, Sabia S, Singh-Manoux A. Association of Metabolic Syndrome With Incident Dementia: Role of Number and Age at Measurement of Components in a 28-Year Follow-up of the Whitehall II Cohort Study. Diabetes Care. 2022 Sep 1;45(9):2127-2135.
View publication - Machado-Fragua MD, Landré B, Chen M, Fayosse A, Dugravot A, Kivimaki M, Sabia S, Singh-Manoux A. Circulating serum metabolites as predictors of dementia: a machine learning approach in a 21-year follow-up of the Whitehall II cohort study. BMC Med. 2022 Sep 27;20(1):334.
View publication - Machado-Fragua MD, Struijk EA, Ballesteros JM, Ortolá R, Rodriguez-Artalejo F, Lopez-Garcia E. Habitual coffee consumption and risk of falls in 2 European cohorts of older adults. Am J Clin Nutr. 2019 May 1;109(5):1431-1438.
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