Our teams: EpiAgeing
| I am Professor of Neurology at the University of Paris Cité, at the Centre for Cognitive Neurology at Lariboisière - Fernand Widal Hospital. My research areas are: epidemiology of cognitive disorders in the general population, biological biomarkers of Alzheimer's disease, the impact of APOE4 on cognition, clinical trials in the field of Alzheimer's disease, and the development of digital tools to assess cognitive impairment. I set up the CHOLINE-2 study, aimed at evaluating the impact of donepezil on the initial management of Alzheimer's patients with positive biomarkers, and developed the MemScreen application on smartphones, aimed at assessing primary care patients with cognitive complaints. |
Research interests
- Alzheimer’s disease and related dementias
- CSF and plasma biomarkers
- APOE
Key publications
- Régy M, Dugravot A, Sabia S, Bouaziz-Amar E, Paquet C, Hanseeuw B, Singh-Manoux A, Dumurgier J. Association between ATN profiles and mortality in a clinical cohort of patients with cognitive disorders. Alzheimer's research & therapy 2023;15:77.
View publication - Dumurgier J, Sabia S, Zetterberg H, Teunissen CE, Hanseeuw B, Orellana A, Schraen S, Gabelle A, Boada M, Lebouvier T, Willemse EAJ, Cognat E, Ruiz A, Hourregue C, Lilamand M, Bouaziz-Amar E, Laplanche JL, Lehmann S, Pasquier F, Scheltens P, Blennow K, Singh-Manoux A, Paquet C. A Pragmatic, Data-Driven Method to Determine Cutoffs for CSF Biomarkers of Alzheimer Disease Based on Validation Against PET Imaging. Neurology 2022;99:e669-e678.
View publication - Régy M, Dugravot A, Sabia S, Fayosse A, Mangin JF, Chupin M, Fischer C, Bouteloup V, Dufouil C, Chêne G, Paquet C, Hanseeuw B, Singh-Manoux A, Dumurgier J. Association of APOE ε4 with cerebral gray matter volumes in non-demented older adults: The MEMENTO cohort study. NeuroImage 2022;250:118966
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