InfaDiet is a collaborative project, which aims at studying the influence of infant feeding (milk components & complementary feeding practices) on the child’s health (growth, infections and allergic symptoms) and neurodevelopment. Our main hypothesis is that the beneficial influence of breastfeeding on the child’s health and development is explained by nutritional components of breast milk but also by association of breastfeeding practices with specific complementary feeding practices, such as the more frequent use of fruit and vegetable. The recent evolution of formula milk composition (enrichment with long chain PUFA or with pre/probiotics) offers the opportunity to examine potential nutritional hypothesis, independently of breastfeeding-related practices. Furthermore, we propose to explore breast milk composition, with large-scale non-targeted methods, already developed, to highlight specific components related to the child’s health and neurodevelopment. In this project, child health will be defined by height and weight growth, occurrence of infections and incidence of allergy-related diseases.

Schéma projet InfaDiet bloc texte


The project is based on two French birth cohorts: EDEN and ELFE. The 1st work package will be devoted to the influence of essential nutrients (lipids and proteins) in breast and formula milk. The 2nd work package will be devoted to other components, recently added into formula milk such as pre- and probiotics or only present in breast milk such as complex HMO, immune or inflammatory factors. Breast milk analyses are based on large-scale non-targeted (“omic”) methods. In the 3rd work package, we will extend our approach to other aspects of infant feeding, such as timing and type of foods used during the complementary feeding period (including organic foods).


The present study funded by an ANR grant (ANR-19-CE36-0008).


  • Camier A, Chabanet C, Davisse-Paturet C, Ksiazek E, Lioret S, Charles MA, Nicklaus S, de Lauzon-Guillain B. Characterization of Infant Feeding Practices and Related-Family Characteristics in the French Nationwide ELFE Birth Cohort. Nutrients 2020;13(1). doi: 10.3390/nu13010033.
  • Camier A, Davisse-Paturet C, Scherdel P, Lioret S, Heude B, Charles MA, de Lauzon-Guillain B. Early growth according to protein content of infant formula: Results from the EDEN and ELFE birth cohorts. Pediatr Obes 2021;16(11):e12803. doi: 10.1111/ijpo.12803.
  • de Lauzon-Guillain B, Gaudfernau F, Camier A, Davisse-Paturet C, Lioret S, Nicklaus S, Charles MA, Kesse-Guyot E. Characteristics associated with feeding organic foods during complementary feeding: the nationwide Etude Longitudinale Francaise depuis l’Enfance (ELFE) birth cohort. Br J Nutr 2021;126(8):1215-24. doi: 10.1017/S0007114520005097.
  • Payet D, Adjibade M, Baudry J, Ghozal M, Camier A, Nicklaus S, Adel-Patient K, Divaret-Chauveau A, Gauvreau-Beziat J, Vin K, et al. Organic Food Consumption During the Complementary Feeding Period and Respiratory or Allergic Diseases Up to Age 5.5 Years in the ELFE Cohort. Front Nutr 2021;8:791430. doi: 10.3389/fnut.2021.791430
  • Adjibade M, Davisse-Paturet C, Bernard JY, Adel-Patient K, Divaret-Chauveau A, Lioret S, Charles MA, de Lauzon-Guillain B. Enrichment of infant formula with long-chain polyunsaturated fatty acids and risk of infection and allergy in the nationwide ELFE birth cohort. Allergy 2022;77(5):1522-33. doi: 10.1111/all.15137.
  • Adjibade M, Davisse-Paturet C, Divaret-Chauveau A, Adel-Patient K, Raherison C, Dufourg MN, Lioret S, Charles MA, de Lauzon-Guillain B. Enrichment of Formula in Probiotics or Prebiotics and Risk of Infection and Allergic Diseases up to Age 5.5 Years in the Nationwide Etude Longitudinale Francaise depuis l’Enfance (ELFE) Cohort. J Nutr 2022;152(4):1138-48. doi: 10.1093/jn/nxac013.
  • Camier A, Cisse AH, Lioret S, Bernard JY, Charles MA, Heude B, de Lauzon-Guillain B. Infant feeding practices associated with adiposity peak and rebound in the EDEN mother-child cohort. Int J Obes (Lond) 2022;46(4):809-16. doi: 10.1038/s41366-021-01059-y.
  • Delvert R, Ghozal M, Adel-Patient K, Kadawathagedara M, Heude B, Charles MA, Annesi-Maesano I, Tafflet M, Leynaert B, Varraso R, et al. Maternal Diet Quality during Pregnancy and Allergic and Respiratory Multimorbidity Clusters in Children from the EDEN Mother-Child Cohort. Nutrients 2022;15(1). doi: 10.3390/nu15010146.
  • Martinot P, Adjibade M, Taine M, Davisse-Paturet C, Lioret S, Charles MA, de Lauzon-Guillain B, Bernard JY. LC-PUFA enrichment in infant formula and neurodevelopment up to age 3.5 years in the French nationwide ELFE birth cohort. Eur J Nutr 2022;61(6):2979-91. doi: 10.1007/s00394-022-02863-6.
  • Tamazouzt S, Adel-Patient K, Deschildre A, Roduit C, Charles MA, de Lauzon-Guillain B, Divaret-Chauveau A. Prevalence of Food Allergy in France up to 5.5 Years of Age: Results from the ELFE Cohort. Nutrients 2022;14(17). doi: 10.3390/nu14173624.
  • Adam T, Divaret‐Chauveau A, Roduit C, Adel‐Patient K, Deschildre A, Raherison C, Charles MA, Nicklaus S, de Lauzon‐Guillain B. Complementary feeding practices are related to the risk of food allergy in the ELFE cohort. Allergy 2023. doi: 10.1111/all.15828.
  • Marinho AR, Correia D, Bernard JY, Heude B, Lopes C, de Lauzon-Guillain B. Macronutrient intake during infancy and neurodevelopment in preschool children from the EDEN mother-child cohort. Eur J Clin Nutr 2023. doi: 10.1038/s41430-023-01273-z.
  • Somaraki M, de Lauzon-Guillain B, Bernard JY, Tafflet M, Charles MA, Nicklaus S. Hydrolysed proteins in infant formula and child neurodevelopment up to the age of 3.5 years: the nationwide Etude Longitudinale Francaise depuis l’Enfance (ELFE) birth cohort. Br J Nutr 2023:1-12. doi: 10.1017/S0007114523000211.
  • Camier A, Cisse AH, Heude B, Nicklaus S, Chabanet C, Bernard JY, Lioret S, Charles MA, de Lauzon-Guillain B. Infant feeding practices and body mass index up to 7.5 years in the French nationwide ELFE study. Pediatr Obes 2024:e13121. doi: 10.1111/ijpo.13121.
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