PhD student: Léa Lefebvre

Title: Impact of urban environment and air pollution on cardiometabolic health in adolescents: Findings from the PARIS birth cohort

Supervisors: Prof. Isabelle Momas, Dr Céline Roda

Doctoral school: DS 393 Pierre Louis of Public Health: Epidemiology and Biomedical Information Sciences

Promotion: 2021

Funding: ADEME / Université Paris Cité

Thesis abstract:

Cardiovascular diseases are the leading cause of death worldwide. The metabolic syndrome, a cardiovascular risk factor, represents a cluster of metabolic abnormalities (excess weight, hypertension, dyslipidemia…). Currently, there is no consensus on the definition of metabolic syndrome in children/adolescents.

Urban planning is a well-known determinant of health, but the association of the urban environment with cardiometabolic health in adolescents is poorly investigated.

Using data from a well-established birth cohort, the PARIS “Pollution and Asthma Risk: an Infant Study” cohort, this thesis aims to gain a better understanding of the relations between the urban environment, behaviors, lifestyle, exposure to air pollution and cardiometabolic health in adolescents. The objectives are:

1. To identify life-long body mass trajectories, from birth to adolescence, and phenotypes of cardiometabolic health in adolescence;

2. To assess, using a holistic approach, urban environmental exposures, taking into account the different places of life (home, daycare, school);

3. To quantify the association of the urban environment with cardiometabolic health, by examining the potential mediating (behavior/lifestyle, air pollution) and modifying (social level, sex) effects on this relationship.


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