PhD student: Antoine Citerne
Title: Exposure to traffic-related air pollution and morbidity at 15 years in the PARIS birth cohort
Supervisors: Pr Isabelle Momas, Dr Fanny Rancière
Doctoral school: DS 393 Pierre Louis of Public Health in Paris: Epidemiology and Biomedical Information Sciences
Funding: Internat en Pharmacie hospitalière : Pratique et Recherche (AP-HP) (année recherche et stages validants)
Thesis abstract: Adolescent health is relatively poorly documented, yet adolescence is a key stage in life marked by a variety of health problems, including disability and chronic diseases such as asthma and allergies. In this context, birth cohorts are a useful tool for studying the natural history of biological, clinical or functional disturbances likely to occur throughout childhood and adolescence. It is recognized that these morbidities are multifactorial, originating both in genetic predisposition and in behavioral and environmental risk factors. Among the latter, the impact of atmospheric pollution, particularly from motor vehicles, is increasingly mentioned. Despite an abundant literature, published results remain contradictory.
Furthermore, in the context of the health crisis linked to the SARS-CoV-2 coronavirus, the development of COVID-19 disease and its associated factors in children and adolescents are poorly understood, and the effects of lockdown on adolescent health could be unprecedented in terms of both physical and mental health.
In this context, the objectives of this thesis are:
- firstly, to document the morbidity of adolescents in the PARIS cohort at adolescence:
– in the short term, in relation to the SARS-CoV-2 coronavirus health crisis:
- to describe the morbidity of adolescents in the PARIS cohort during the lockdown period from March 17 to May 10, 2020, linked or not to COVID-19;
- to assess the impact of the health situation and lockdown on the morbidity of adolescents in the PARIS cohort;
– over the first 15 years, in relation to the natural history of pathologies, to identify allergic trajectories within the PARIS cohort.
- secondly, to assess associations between exposure to traffic-related air pollution (TRAP) and these different morbidities.