Our research aims to highlight the role of “timing” and “duration” of exposure to a risk factor in shaping risk of ADRD. Much of the existing research comes from studies that recruit persons 65 years and older and then follow them for incidence of ADRD. Results from such studies contain both the true causal effect and that due to reverse causation, the latter being common when the risk factor is modified in the preclinical phase of AD/dementia.
We use two strategies to examine the role of risk factors:
- estimate the risk associated with exposures measured at 50, 60, and 70 years using time to event analyses;
- model the trajectory of risk factors over 30 years before ADRD diagnosis.
A Singh-Manoux, S Sabia, M Machado, C Ben-Hassen, F van der Heide, A Dugravot, A Fayosse