– Pain and chronic inflammatory rheumatism project: The question is whether sociodemographic factors are associated with the development of pain in inflammatory diseases of the musculoskeletal system, after taking account of disease-specific characteristics. To do this, we used data from two major databases: ESPOIR, a large cohort of early-stage RA patients, and the DESIR cohort.
– Gender and inflammatory rheumatism: does gender have an impact on the treatment trajectories of these patients? The hypothesis is that some patients may have been in high persistent activity because they did not use an effective treatment such as biotherapy, because of their gender (study conducted in the DESIR cohort).
– Impact of pregnancy on chronic inflammatory diseases: we have initiated a prospective cohort of patients with inflammatory diseases of the MSK (rheumatoid arthritis or spondyloarthritis) with a desire for pregnancy or a pregnancy in progress. GR2-RIC is still ongoing, actively recruiting since 2016, and currently involves more than 20 centres across France. In our first pooled analysis, including 332 pregnancies from 304 women with axial spondyloarthritis, 98.8% of pregnancies resulted in a live birth. Pregnancy and neonatal outcomes were very favourable, with rates of 4.9% for preterm birth and 9.5% for gestational age (Meissner Y, Strangfeld A, Molto A, et al. Ann Rheum Dis. 2022).
– Impact of the environment on chronic inflammatory diseases: collaboration with the European Prospective Investigation into Cancer and nutrition (EPIC) cohort (EPIC is a consortium of European cohorts analysing the relationships between diet, lifestyle and environmental factors and the onset of cancer or other chronic diseases. It is based on a cohort of 521,000 men and women recruited in 10 European countries. Several studies are underway or planned to investigate the associations between diet (using several innovative indices or holistic scores), lifestyle, environmental exposures and the risk of chronic inflammatory diseases.