This project aims to take a structured and systematic examination of the link between disease, including multimorbidity, and disability in population-based cohort studies. The aims are:
- to map the link between disease and functioning outcomes, and the manner in which age affects this mapping.
- to identify disruptors within the system by identifying factors that offset the link between disease and disability, e.g. better controlled chronic diseases, environments favourable to a healthy lifestyle, etc.
This project uses multi-state models with longitudinal data, with a view to identifying how specific sets of risk factors (socioeconomic, behavioural, clinical profile) affect the transitions from a disease state to impaired function, disability and death. The objective is to identify key factors that shape health transitions to inform prevention.
A Singh-Manoux, S Sabia, B Landré, A Schnitzler, L Jacob, A Dugravot, A Fayosse