Project
Objectives
The two studies aimed:
- to study the influence, on the risk of cancer in children, of the course of pregnancy, of the characteristics of the child at birth, of the environment of the child in utero or during childhood , his lifestyle.
- to identify genetic predisposition factors.
- to look for possible interactions between genetic factors and environmental factors
Methods
The cases were identified in the pediatric oncology departments; the controls were recruited from telephone lists respecting quotas of age, gender and household size.
Case and control mothers were interviewed by telephone.
Blood or saliva samples were taken subject to informed consent.
Inclusions
| ESCALE, 2003-2004 | ESTELLE, 2010-2011 | |||
| Interviews | DNA | Interviews | DNA | |
| Leukaemia | 764 | 723 | 746 | 707 |
| Lymphoma | 295 | 257 | 344 | 317 |
| Brain tumour | 209 | 176 | 302 | 254 |
| Neuroblastoma | 191 | 154 | 200 | 166 |
| Nephroblastoma | – | – | 119 | 106 |
| Hepatoblastoma | – | – | 22 | 19 |
| Controls | 1681 | 810 | 1421 | 894 |
Regulatory aspects
ESCALE CNIL n°902162 – RBM (DGS 2003/0259)
ESTELLE CNIL n°908283 – hors RBM -CPP Ile de France IV, 2008/12NICB
Collaborations for genetic analysis : CNRGH/CEA, Institut Pasteur Lille
