Presentation by Elissa Msallem, PhD student, at the ISEE young Rennes held from June 5 to 7, 2024 in Rennes who presented the following project in speed talk form: Maternal lifestyle factors during pregnancy and the risk of childhood lymphoma – The ESCALE and ESTELLE studies (SFCE) in the session “Early life exposures and birth outcome”. https://iseeyoung2024.sciencesconf.org/
- Abstract presenter: Elissa Msallem
- Abstract title: Maternal lifestyle factors during pregnancy and the risk of childhood lymphoma – The ESCALE and ESTELLE studies (SFCE)
- Authors: Elissa Msallem, Hélène Pacquement, Marlène Pasquet, Laurence Brugieres, Judith Landman Parker, Nathalie Garnier, Anne Lambilliotte, Laure Faure, Jacqueline Clavel, Audrey Bonaventure
- Aurélie Danjou : Perinatal exposure to traffic-related air pollution and risk of childhood leukemia in France https://iseeyoung2024.sciencesconf.org/data/pages/Abstracts_ISEE_Young24.pdf
- Abstract presenter: Aurélie Danjou
- Abstract title: Perinatal exposure to traffic-related air pollution and risk of childhood leukemia in France
- Authors: Aurélie Danjou, Antoine Lafontaine, Bénédicte Jacquemin, Danielle Vienneau, Kees De Hoogh, Jacqueline Clavel, Stéphanie Goujon
Abstract: Introduction: Traffic-related air pollution is suspected of increasing the risk of childhood acute leukemia (AL). We tested this hypothesis in individuals across metropolitan France, targeting the perinatal exposure window.
Methods: The GEOCAP case-control study includes 581 cases of acute lymphoblastic leukemia (ALL) and 136 cases of acute myeloid leukemia (AML), born and diagnosed between 2010 and 2015 (French national registry of childhood cancer), and 11,908 controls representative of births residing in metropolitan France over this period. Exposures included major roads length in 500 m buffers, and annual mean concentrations of nitrogen dioxide (NO2), fine particulate matter (PM2.5) and black carbon (BC, constituent of PM2.5) assessed by land use regression models, estimated at the geocoded residential addresses at birth. Odds ratios (OR) and 95% confidence intervals (CI) were estimated for ALL and AML using polytomous logistic regression models. Additional analyses were carried out: by stratifying on the degree of urbanization; with restrictions to the best geocoded addresses; and adjusting for potential confounding factors.
Results: Positive associations were observed between risk of AL and PM2.5 concentrations (OR ALL=1.14, 95%CI=1.08-1.20 and OR AML=1.12, 95%CI=1.00-1.25 for an increment of 2 µg/m3 (interquartile)). An increase in AML risk was observed for the highest levels of NO2, although not statistically significant (OR=1.38, 95%CI=0.92-2.10 for the third versus first tertile of exposure). The risk of ALL was associated with BC in rural and less populated urban areas (OR=1.90, 95%CI=1.22-2.97 and OR=1.58, 95%CI=1.16-2.17 for per 0.5 µg/m3, respectively), but not in the overall population. There was no association with the length of major roads. Results were consistent in all the additional analyses.
- Matthieu Mancini – Residential proximity to vines and childhood cancer risk in mainland France: GEOCAP case-control study, 2006-2013
- Abstract presenter: Matthieu Mancini
- Abstract title: Residential proximity to vines and childhood cancer risk in mainland France: GEOCAP case-control study, 2006-2013
- Authors: Danielle Awounou, Matthieu Mancini, Perrine de Crouy-Chanel, Laurence Guldner, Jacqueline Clavel, Stéphanie Goujon
Abstract: Introduction: Several epidemiological studies suggest a link between household pesticide use, parental occupational exposure to pesticides and the risk of childhood cancer. The literature on environmental exposure to agricultural pesticides is however more limited. The objective of the study was to evaluate the risk of acute leukemia (AL) and embryonal tumours (ET) in children living close to vines, a crop subject to intensive pesticide use.
Methods: The study is part of the French national registry-based GEOCAP program. Over 2006-2013 period, we included 3,711 AL cases and 2,761 ET cases (neuroblastoma, retinoblastoma, Wilms tumour and rhabdomyosarcoma) under the age of 15 years, and 40,196 controls representative of the same age population. The presence and density of vines within 1,000 m of the geocoded addresses of residence were evaluated by combining three data sources in a geographic information system (GIS): Corine land cover, graphic parcel register, and information from BD TOPO® about vines and orchards. We estimated odds ratios (ORs) and 95% confidence intervals using unconditional logistic regression models adjusted for age and we carried out several sensitivity analyses taking into account geocoding uncertainty, density of other crops and potential demographic and environmental confounders.
Results: About 10% of the controls lived within 1 km of vines, with regional variations ranging from <1% to 38%. We observed a 5% increase in the risk of lymphoblastic AL (ALL) and neuroblastoma for a 10% increase in vines density (OR=1.05 [1.00-1.09] and OR=1.05 [0.98-1.13], respectively), with a regional heterogeneity. No association was observed with retinoblastoma, Wilms tumor or rhabdomyosarcoma.
Conclusion: Based on objective indicators built using GIS tools, we evidenced an increase in ALL and neuroblastoma risk in children living near vines, suggesting a role of residential exposure to agricultural pesticides, which requires further investigation.
